Allergy comprises of a spectrum of diseases—atopic dermatitis, rhinoconjunctivitis, asthma, food allergies, and drug allergies—that are all driven by IgE-mediated hypersensitivity. The prevalence of atopy, the genetic tendency to develop allergic diseases, has more than doubled in the last 30 years. Severe allergies can impact an individual’s quality of life and can even be life-threatening. In this webinar, we look at the pathophysiology underlying allergic diseases and its various clinical presentations. While allergen avoidance continues to be a mainstay in preventing allergy attacks, we review the pharmacotherapeutic options available to manage allergic diseases. Finally, we discuss compounding opportunities for patients with allergies, including extemporaneous formulations (sodium cromolyn ointment for atopic dermatitis and diphenhydramine troches for rhinitis); customized immunotherapy to induce allergen tolerance; and the avoidance of specific excipients in drug preparations.