Despite 1/5 persons suffering from chronic pain, there remains inadequate medication options effective in alleviating suffering and restoring function.  Clinicians must rely mainly on medications that either have potentially serious adverse effects (e.g., addiction to opioids), were originally marketed for other medical conditions (e.g., antidepressants), or have minimal scientific evidence to support its efficacy.

The use of compounded percutaneous medications allows clinicians to consider the different mechanisms involved in a patient’s chronic pain condition and the different classes of drugs available to target these mechanisms when formulated in an appropriate and customized manner. This presentation will review clinical cases where personalized medication approaches led to successful pain reduction; clinical reasoning and important information to be aware of when proceeding with a compounded percutaneous medication.