Course opens: 

Personalized Analgesic Medications: Targeting Pain at Its Source

Course Outline*

MODULE 1: The Current Landscape

  • The Impact of Chronic Pain
    • Prevalence
    • Economic burden
    • Quality of life
    • Healthcare system
  • Challenges in Pain Management
    • Systemic side effects
    • Opioid use disorder
    • Patient non-compliance
    • Education
  • Reevaluating Pain Management – Targeting Pain at its Source
    • Pharmaceutical compounding


MODULE 2: Types of Pain

  • Nociceptive Pain
    • Somatic nociception
    • Visceral nociception
    • Inflammatory nociception
  • Neuropathic Pain
  • Functional Pain
  • Mixed Pain


MODULE 3: Pain Pathways & Neural Systems

  • The Peripheral System
    • Excitatory influence: H+ ions, ATP, glutamate, serotonin, histamine, substance P, CGRP, bradykinin, prostaglandin, NGF, TNF, ILs, endothelins, and change in membrane potential
    • Inhibitory influence: GABA, opioids, and cannabinoids
  • The Dorsal Horn
    • Presynaptic terminals
    • Excitatory interneurons
    • Inhibitory interneurons
    • Postsynaptic cell bodies
  • The Ascending System
  • The Brainstem
  • The Brain
  • The Descending System
  • Pain Pathways – Taken Together

MODULE 4: The Chronicity of Pain – Sensitization

  • Peripheral Sensitization
    • Allodynia
    • Hyperalgesia
    • Unaddressed acute nociception
    • Neuroma formation
    • Vascular changes
  • Central Sensitization
    • Wind-up
    • Disinhibition


MODULE 5: Analgesic Pharmacology – Dynamics, Efficacy, Safety, & Dosing

  • Peripheral-Acting Drugs
    • Non-steroidal anti-inflammatory drugs
      • Celecoxib
      • Diclofenac
      • Indomethacin
      • Ketoprofen
      • Meloxicam
      • Naproxen
      • Paracetamol
      • Discussion Break (20 min)
    • Corticosteroids
      • Dexamethasone
    • Local anesthetics (sodium channel blockers or stabilizers)
      • Benzocaine
      • Bupivacaine
      • Lidocaine
      • Prilocaine
      • Tetracaine
      • Break (20 min)
    • Serotonin (5-HT) receptor antagonists
      • Amitriptyline
  • Peripheral- and Dorsal Horn-Acting Drugs
    • Transient receptor potential (TRP) channel agonists
      • Capsaicin
      • Menthol
    • NMDA receptor antagonists
      • Amantadine
      • Carbamazepine
      • Dextromethorphan
      • Guaifenesin
      • Ketamine
      • Discussion Break (20 min)
    • GABA agonists
      • Baclofen
      • Diazepam
    • Opioids
      • Buprenorphine
      • Codeine
      • Loperamide
      • Methadone
      • Morphine
      • Oxycodone
      • Tramado
      • Discussion Break (20 min)
    • Cannabinoids
      • Palmitoylethanolamide
      • Cannabidiol
  • Dorsal Horn-Acting Drugs
    • Voltage-gated calcium channel (VGCC) blockers
      • Amlodipine
      • Gabapentin
      • Nifedipine
      • Pregabalin
      • Ziconotide
      • Discussion break (20 min)
  • Ascending-Acting Drugs
    • Sodium channel blockers
  • Descending-Acting Drugs
    • Serotonin norepinephrine reuptake inhibitors (SNRIs)
      • Amitriptyline
      • Despiramine
      • Duloxetine
      • Fluoxetine
  • Summary of Analgesic – Pharmacodynamics and Anatomical & Clinical Targets
    • Group activity (20 min)


MODULE 6: Topical Treatments – Skin Physiology and Delivery Systems

  • Advantages and limitation of topical therapy
  • Skin Physiology
  • Delivery systems
  • Special formulation considerations


MODULE 7: The Cases

  • Osteoarthritis (inflammation)
  • Low Back Pain (mixed)
  • Diabetic Neuropathy (neuropathic)
  • Anal Fissures (nociceptive)
  • Fibromyalgia (functional)
  • Post Fracture/Surgery (Neuroma – Preventing Addiction)
  • Opioid Use Disorder


*Subject to change.


Intended audience

Pharmacists, Physicians, Naturopathic Doctors, and other healthcare providers engaged in analgesic therapy.


This learning activity has received financial support from MEDISCA Inc. in the form of an educational grant.


The live activity workbook is copyright © 2008-2020 LP3 Network

Course summary
Available credit: 
  • 1.60 CEU (ACPE)
  • 16.00 Contact Hours
Diplomate, American Board of Anesthesiology; Diplomate, American Board of Pain Medicine; Facilitator, LP3 Network
Disclosure: None

Dr. de la Garza is a board certified physician who practices multidisciplinary interventional pain management in four offices in the Tampa Bay area. He performs interventional pain procedures, specializing in minimally invasive surgical decompression of herniated discs and spinal stenosis, implantable intrathecal pumps, spinal cord stimulation, and peripheral nerve stimulation. Dr. de la Garza has published numerous research papers and abstracts, and has presented at regional and national academic conferences on the topics of anesthesia and pain medicine. He is also a consultant for numerous pharmaceutical and medical device manufacturers.

Dr. de la Garza received a Bachelor of Science in Molecular Biology and a Bachelor of Arts in Chemistry from Texas Lutheran College in Seguin, Texas. He graduated from the University of Texas Southwestern Medical School in 2001 and performed his anesthesia residency at the University of South Florida College of Medicine, Department of Anesthesiology and Critical Care from 2001 to 2005. He then completed an interventional pain medicine fellowship at The Cleveland Clinic, in the Department of Anesthesia and Pain Management.


Facilitator, LP3 Network; Vice President, Compounding Compliance, Gates Healthcare Associates; Surveyor and Accreditation Expert, Accreditation Commission for Health Care (ACHC/PCAB); Fellow, International Academy of Compounding Pharmacists (IACP); Fellow, American College of Apothecaries (ACA); Professor of Pharmacy Practice (retired), University of Findlay.
Disclosure: Surveyor, Accreditation Commission for Health Care (ACHC/PCAB); Consultant, Gates Healthcare Associates.

Dr. Ken Speidel is recognized for his broad experience in pharmacy practice and education, including his national recognition as a pharmacotherapeutic specialist in endocrinology and pain management.  In addition, Dr. Speidel provides expert training in sterile and non-sterile compounding processes in the acute care, community, outpatient, and 503A/503B practice sectors.  He has been instrumental in the development of national standards for pharmacy compounding practices and provides consulting services to many organizations including boards of pharmacy as well as hospitals and health systems in the United States and abroad.

 In addition to his worldwide consulting and educational work, Dr. Speidel is a retired Professor of Pharmacy Practice from the University of Findlay. He has also assisted in the development and facilitation of many nationally recognized educational programs, approved by the Accreditation Council for Pharmacy Education (ACPE). Moreover, Dr. Speidel was an advisor for the development of the Pharmacy Compounding Accreditation Board (PCAB) and remains a surveyor and accreditation expert for PCAB/ACHC (Accreditation Commission for Health Care). Dr. Speidel has served as multi-term president of the National Home Infusion Association (NHIA) as well as president of the Hospice of Portage, a large hospice program in the United States.

 Dr. Speidel received a Bachelor of Science and Doctor of Pharmacy from Ohio Northern University and has completed postdoctoral training in nutritional support and functional medicine. He has been awarded Fellowship status with the International Academy of Compounding Pharmacists (IACP) as well as the American College of Apothecaries (ACA).


Medical Editor Team Lead
Disclosure: None





This activity is eligible for CPE credits. Please see final activity announcement for details.



This program may be eligible for AMA PRA Category 2 CreditsTM. Physicians are advised to assess the program for applicability to their practice and may contact their State Medical Board on eligibility for AMA PRA Category 2 CreditsTM.



This activity has not been formally reviewed by the CFPC; however, it is eligible for non-certified credits. Mainpro+ participants may also earn additional certified credits by completing a Linking Learning exercise.


Other international participants should verify with their respective medical board for accreditation equivalency.


In the event that LP3 Network cancels a course, LP3 Network's sole liability shall be course repayment. In no event shall LP3 Network be responsible for any costs related to travel and/or accommodation. A written request must be sent to LP3 Network Inc. requesting ‘Cancellation without Transfer’ to an alternate live activity event date. If cancellation occurs at greater than or equal to 31 days from live activity event date, then registrant will receive a 75% refund; 15-30 days a 50% refund; and less than or equal to 14 days no refund. There are no refunds, returns, or transfer requests upon purchase of a home study, digital work book, webinar, and eLearning modules. LP3 NETWORK INC. shall be excused from any delay caused by reason of any occurrence or contingency beyond its reasonable control (a “Force Majeure”), including but not limited to, acts of God, hurricane, earthquake, labour disputes, strikes, riots, war, and governmental requirements. The obligation to pay money to LP3 NETWORK INC. in a timely manner is absolute and shall not be subject to this Force Majeure provision. In such event, LP3 NETWORK INC. will not issue any refunds, only transfer to an alternate live activity event date.


The transfer policy is only in effect if requested greater than or equal to 14 days prior to the original live activity date. Failure to submit the “Transfer Request” at least 14 days prior to the original live activity date will default to the “Cancellation and Refund Policy”. The transfer policy can only be applied one (1) time. Transfer to a new live activity date must be within the current calendar year. Failure to attend the new live activity will result in no refund and will no longer be transferable. Confirmation of the new activity date is subject to approval by LP3 Network based on the number of available seats within the selected live activity. There are no refunds, returns, or transfers upon purchase of the home study.


Please login to Enroll or Add to Waitlist
Please login to Enroll or Add to Waitlist
Please login to Enroll or Add to Waitlist
Please login to Enroll or Add to Waitlist
Please login to Enroll or Add to Waitlist
Please login to Enroll or Add to Waitlist
Please login to Enroll or Add to Waitlist
Course expires: