DESCRIPTION:

This activity affords the student pharmacist the opportunity to complete master formulation records, while preparing compounded medications in the form of suppositories and troches, each of which requires mold filling. The student pharmacist will recognize and utilize methods to ensure accurate metered-dosing when preparing compounded medications. Emphasis is on the management of the master formulation record, ensuring completeness of recordings and consistency in performance.

LEARNING OBJECTIVES

• Prepare two compounded medications from established master formulation records employing molds; suppositories and troches are featured.
• Discuss the importance of implementing a set of rules to ensure dosing accuracy, precision, and repeatability.
• Discuss the importance of delivery system selection resulting in appropriate rates of diffusion, dissolution, dispersion and/or disintegration.
• Review preparatory procedures specific to mold filling, preparatory state of matter, and final dosage form state of matter.
• Assess the impact of active pharmaceutical ingredient solubility, concentration, and displacement characteristics in a mixture.
• Address labelling and packaging requirements for mold-filled compounded medications.
• Identify handling and storage requirements for mold-filled compounded medications.
• Assign beyond-use dates for compounded medications in accordance with standards of practice.
• Validate compounded medications for their required qualitative and quantitative parameters through internal and external testing.  
• Verify the accuracy, precision, and repeatability of three critical determinants of a mold-filled compounded medication’s efficacy, reliability, and validity: the master formulation record’s detailing, the displacement factor, and human performance measures.
• Manage the verification process for finished compounded preparations, ensuring identity, strength, and stability.